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Early trials reported it to be generally well tolerated at low doses, but these studies were small and of short duration
In this study, correlations were found between antioxidant enzyme activities and pesticide concentrations (Table III), SOD activity was correlated with -HCH and cyclodienes content (r = 0.45 and r = 0.39, respectively), GPx activity was correlated with concentrations of -HCH and chlordanes (r = 0.35 and r = - 0.36, respectively), and GR activity was correlated with aldrin concentration (r = - 0.50)
All mice were maintained in a HEPA-filtered ventilated rack system at the Animal Facility of the Assembly Building of The Hillman Cancer Center at the University of Pittsburgh School of Medicine