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Helpful questions include What changes do you typically see over time How do you define progress beyond the number on the scale When do we reassess whether this medication still aligns with my goals While clinical trials report average outcomes across large populations, many clinicians focus on a broader picture that includes metabolic health, physical function, and sustainability rather than weight alone

Burnstock, Advances in Experimental Medicine and Biology 986 (2013) 112

Dodd RD, Lee CL, Overton T, Huang W, Eward WC, Luo L, et al

And for some with specific risk factors, lifelong GLP-1 therapy is the best plan