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The groups given daily gymnema supplementation (400 mg to 10 g for 21 days to 20 months) exhibited lower fasting blood sugar, lower blood sugar after meals, and lower HbA1C compared to before they started taking it

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This stability made it a viable drug candidate where human GLP-1 had failed

In endothelial progenitor cells (EPC) derived from human peripheral blood mononuclear cells, high glucose conditions downregulate GLP-1-R and sirtuin 1 ( SIRT1 ) expression, leading to impaired cell functions and increased apoptosis via elevated acetylated p53 levels

This helps address hyperphagia and prevents the gastrointestinal strain caused by overeating