Wide release: March 22, 2026
PMID 11863489
Benefits (Research Focus) NNMT inhibition studied as a selective small-molecule inhibitor of nicotinamide N-methyltransferase NAD+ preservation investigated for preservation of cellular NAD+ pools and downstream sirtuin pathway activity Adipose tissue research explored for lipolysis markers and fat-mass partitioning in DIO rodent models Skeletal muscle metabolism examined for endpoints related to muscle aging and sarcopenia models Metabolic signaling researched for glucose homeostasis and insulin sensitivity endpoints in metabolic disease models What Researchers Look At NNMT enzymatic activity and 1-methylnicotinamide (1-MNA) tissue concentrations Intracellular NAD+ / NADH ratio and downstream sirtuin (SIRT1/SIRT3) activation Body composition, fat mass, and lean mass partitioning in DIO rodent models Adipocyte lipolysis markers and adipose tissue inflammation profiles Glucose tolerance, insulin sensitivity, and hepatic steatosis endpoints Quick Specs Form: Lyophilized white powder Net Content: 50 mg per vial (as iodide salt) Quantity: 1 vial Appearance: White to off-white lyophilizate Reconstitution: Bacteriostatic or sterile water (added by the end researcher) Purity: 99% by HPLC Identity: MS-verified (per COA) Storage: Protect from light Identity Basics Compound: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) Synonyms: 5-Amino-1-methylquinolinium
If the use of NSAIDs can lead to peptic ulcer disease, it is not surprising that BPC-157, by eliminating their cytotoxic effect, will protect the stomach from their formation, even in the case of simultaneous use as well as regeneration after therapy with drugs from the NSAID group
While injectable B12 is generally considered more effective, oral supplements are an acceptable alternative depending on the needs of the patient
improved recovery in crush injury models (PMID: 31266512) Bone: Accelerated fracture healing and pseudoarthrosis repair in animal models (PMID: 10071911) Muscle: Faster recovery from muscle crush injuries and systemic corticosteroid-induced damage (PMID: 40756949) TB-500 Research Evidence TB-500 is a synthetic fragment of Thymosin Beta-4, often used as an alternative to the full-length protein
