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A relatively new addition to the arsenal of antidiabetic compounds studied in relation to Type 2 Diabetes mellitus (T2DM) have been the incretin mimetics, a group of substances that appear to work on the glucagon-like peptide-1 (GLP-1) receptor and enhance insulin secretion from the pancreatic -cells in a glucose-dependent manner, possibly more potently in hyperglycemic conditions, while suppressing glucagon secretion at the same time

The most significant published data comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al

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