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Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

Indeed, the therapeutic effect of silymarin combined with LC on non-alcoholic fatty liver disease in patients was higher that silymarin alone [153]

March 28, 2015

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