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Understanding not just whether something works but for whom it works is a central goal of good research, and it takes time to establish

It has been shown that ROS generation mainly occurs by the activation of a plasma-membrane NADPH oxidase (Drerup et al

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We proposed that the insulinotropic effect of this GLP-1R agonist (GLP-1RA) would synergize with the insulin-sensitizing effect of tesaglitazar to optimize glucose handling, while the body weight lowering effect of the GLP-1RA would buffer against any potential obesogenic activity of PPAR agonism

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