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Following gut immune activation, activated immune cells and effector molecules such as cytokines [e.g., Interleukin-17 (IL-17), Tumor Necrosis Factor-alpha (TNF- )] can promote local inflammatory responses, alter the oral microecological environment, and either inhibit or promote the growth of specific microbial communities, playing a pivotal role in the regulation of oral microbiota (Nagao et al., 2022)

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3.5 Other potential biomarkers associated with PCa In the others category, a total of 12 articles (138, 154, 155, 168176) were included, evaluating 59 potential biomarkers related to PCa ( Supplementary Table 6 )

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