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Another multitarget MOR-DOR agonist, SRI-22141, was tested in the clinically relevant models of HIV neuropathy and chemotherapy-induced peripheral neuropathy, in which it was found that while providing equal or enhanced efficacy versus morphine, the tolerance was significantly reduced, with almost non-dependence during the course of repeated administration [59]

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Yuan M, Tu B, Li HPH, Zhang N,Fan MBJ, Wang W,Shu Z,DuFort CC,Huo S