PMID: 33 GaoY.WangB.HuM.MaY.ZhengB
Reduced methylation due to functional B12 deficiency results in depression, anxiety and poor sleep - common symptoms in CFS Reduced methylation due to functional B12 deficiency, results in lower production of melatonin and poor maturation of the gut Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyalitis (ME) is an ill defined disease that is characterized by a post exercise tiredness or malaise
These metabolites are biologically active, can reduce intravascular oxidative stress, inhibit hepatocyte gluconeogenesis and oxidative stress, increase cardiomyocyte activity, promote vasodilation, protect the cardiovascular system, improve cardiac function, thereby directly or indirectly protecting the cardiovascular system ( 4.3 Nervous system disorder Recently, a protective effect of the GLP-1/GLP-1R axis on ischemic brain injury has been emphasized
Dorer FE, Kahn JR, Lentz KE, Levine M, Skeggs LT
Common side effects are nausea, vomiting and constipation
In the gut Wnt has been shown to be involved in regulated expression of the GCG gene