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In trials where semaglutide was added on to basal insulin with or without metformin, severe hypoglycemia (requiring the assistance of another person) was reported in 1.5% of semaglutide-treated patients

If you notice diminished appetite suppression, lack of expected weight loss, or rising blood glucose despite adherence, discuss with your healthcare provider whether medication potency may be compromised, as clinical factors can mimic degradation

The treatment group lost about 15% body weight (37 lb for a 250 lb individual)

You need a healthcare provider who understands proper dosing protocols and can guide you through each phase of treatment