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Semaglutide and Tirzepatide are active ingredients in FDA-approved medications for medical weight management, while Retatrutide is a newer investigational peptide being studied for its potential metabolic and weight-loss benefits

Additionally, ocrelizumab has shown efficacy specifically in PPMS cases, offering a notable therapeutic option while other interventions for PPMS, are limited [141]

Both methods resulted in a similar decrease in total folate concentration, the former by 38% and the latter by 43%

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