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Clinical evidence for IGF-associated immunosuppression comes from reports of low tumor infiltrating lymphocytes (TILs) in high IGF-1R PCa bone metastases, and genomic aberrations in cancer patients with hyper-progressive disease post-ICB, including mutations in negative IGF regulator IGFBP2 and transcriptional upregulation of IGF-1, PI3K-AKT and ERK pathways 17,18

Neurological studies indicate BPC-157 promotes nerve regeneration and protects against various brain injuries

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Oral administration of cobalamin is as effective as parenteral Advantages of oral supplementation are comfort, ease of administration, and cost