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Here, driving expression of MMPs and decreasing the expression of TIMPs, might be a promising target to break down the fibrotic plaque

These symptoms, particularly when accompanied by shortness of breath, require immediate medical evaluation

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E.SwedA.et al (2008)

Patients should seek medical evaluation for severe pain after injury, inability to bear weight, major swelling, deformity, numbness, weakness, fever, signs of infection, worsening abdominal pain, blood in stool, persistent vomiting, chest pain, shortness of breath, or neurological symptoms

4J), some of which were elevated as early as 4872 h after the first injection (Fig