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It selectively hydrolyzes GSH, producing Cys-Gly and 5-oxoproline (a cyclized form of glutamate) (11,51), thereby accelerating formation of the cellular oxidative environment

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This evidence for lesion heterogeneity is important, as it emphasizes that different lesions may require different treatment strategies to enhance remyelination in some, promoting differentiation may suffice, whereas in others, increasing aOPC numbers will be required