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What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology

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This protein-first approach helps create a stable, long-lasting sense of fullness and prevents the rapid blood sugar spikes that can often lead to a binge-restrict cycle

These are the highest-yield nutrition factors linked to hair shedding (especially telogen effluvium) during rapid weight loss: Should I take biotin for hair loss

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Newer Drug: Baxfendy (Baxdrostat) Baxfendy is a newer antihypertensive drug recently approved for resistant/uncontrolled hypertension