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Calcium ionophore A23187 was obtained from J&K Chemical

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Upon sensing decreased ER Ca, stromal interaction molecules translocate to the plasma membrane to colocalize with Orai1 channels, activating store-operated Ca influx to replenish ER Ca stores

A, both differ only slightly, by the size of a methyl group, and in any case, having a glycine (G) in the P1 position is a permitted residue (Figure 1A), as observed in the SCoV M pro cleavage site at the nsp5/6 junction (indicated by * in Figure 2)