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2.5.1 Basic science research In T2DM, impaired autophagy in pancreatic cells leads to the accumulation of metabolic products and damaged organelles (Xxxx et al., 2022)

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Senolytic therapy is included with Tyrosine kinase inhibitor - Dasatinib, taken together with Quercetin

Conclusion In conclusion, we uncovered effects of SAR425899 on metabolic pathways that are relevant for weight loss and weight loss maintenance: a selective reduction in metabolic adaptation and a quantitatively relevant increase in fat oxidation with a parallel increase in ketogenesis

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