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MOTS-c functions as a mitochondrial-derived peptide that activates AMPK (AMP-activated protein kinase) and improves insulin sensitivity through direct mitochondrial signaling
A 1988 study by Alba-Roth et al
Gabriele, S., et al
For people already managing appetite suppression or gastrointestinal changes on GLP-1 medications, this uncertainty matters
Expect waves of mild nausea, bloating, or slower stomach emptying during dose increases, which then settle if you keep the dose the same, as your body needs time to adjust
The peptides won't cause harm, but you're injecting a compound that can't function optimally
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