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In obese subjects, supraphysiological dose of GLP-1 reduces appetite and food intake, which subsequently induces weight loss, alleviates GLP-1 resistance, and increases insulin sensitivity 43

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( E G ) Postprandial GLP-1 ( E ), insulin ( F ), and glucose ( G ) levels in mice fasted overnight and refed HFD for 1 hour after HFD for 10 weeks

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