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Wells GA, Shea B, O'Connell D et al: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

An important hormone produced within the gut is glucagon-like peptide-1

no antibody formation, no cortisol dysregulation, no prolactin elevation throughout study

Summary: The correct dosage of B12 for healthy UK adults is 1.5 micrograms daily for maintenance, whilst treatment of deficiency requires substantially higher doses of 1,0002,000 g orally or 1 mg intramuscular injections

doi: 10.1016/j.cellsig.2019.109395 53 KimBLeeJHJinWJKimHHHaHLeeZH

While this validated the bitter detection system (it was detecting an actual toxin), it obviously couldn't be commercialized