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pumilus overexpressed in B

Additionally, we analyzed postmortem human brain tissue with histopathologically confirmed AD or progressive supranuclear palsy (PSP), an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction, and is neuropathologically defined by NFTs, gliosis and neurodegeneration (104)

Subsequently, the HUVECs are stained with a cell-permeable dye calcein AM (Corning, catalog number 354216) for 30 min, and then observed for capillary-like tubule formation using an inverted microscope

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Simultaneously, GLP-1 receptor activation suppresses glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways that regulate satiety

It serves as the final stage of multiple CVDs, which are highly prevalent, have significant mortality rates, and pose a significant threat to human well-being (95)