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The need for new treatments targeting mpnst: the potential of strategies combining mek inhibitors with antiangiogenic agents

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In the test tube, dihydrolipoic acid is a potent reducing agent with the capacity to reduce the oxidized forms of several important antioxidants, including coenzyme Q 10 , vitamin C, and glutathione ( Figure 5 ) (16, 17)

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76 The third mechanism is TKI acquired resistance such as in HER2-targeted therapy