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[20] designed a dual-layered gene + metabolic inhibition strategy by integrating Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-mediated USP22 knockdown with ND630, a small-molecule ACC1 inhibitor, thereby simultaneously suppressing lipid synthesis at the transcriptional and enzymatic levels

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Molecular formula: C 62 H 98 N 16 O 22 Molecular weight: 1419.5 g/mol CAS number: 137525-51-0 (free base)