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There was no head-to-head trial directly comparing these antidiabetic drug classes

This applies to everyone, but especially to semaglutide users whose gastric motility is already altered

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While semaglutide does not directly increase estrogen, the weight loss it produces can reduce excess aromatase activity and normalize estrogen ratios, particularly in women who are carrying excess visceral fat

Details of the three potentially eligible articles that were excluded from the final analysis are provided in Table 1

Activating ESR1 mutations in hormone-resistant metastatic breast cancer