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According to the SAR of these compounds, the hydrophobic nature positively influenced DPP-4 inhibitory activity, likely due to their lipid/water partition coefficient

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Published studies have investigated GHK-Cu in relation to: extracellular matrix remodelling collagen and elastin biology wound healing angiogenesis inflammatory signalling antioxidant responses skin physiology hair follicle biology connective tissue regeneration Unlike BPC-157 or TB-500, which are primarily discussed in relation to injury and repair models, GHK-Cu is frequently investigated as a broader regulator of tissue remodelling and cellular homeostasis