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doi: 10.1152/ajprenal.00064.2012 102 RiegTGerasimovaMMurrayFMasudaTTangTRoseMet al

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Moderate to high throughput in vitro binding kinetics for drug discovery

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The molecule consists of a modified GLP-1 analog, containing three key amino acid substitutions: Ala8Gly, Gly22Glu, and Arg36Gly, covalently fused to the Fc (constant) region of human immunoglobulin G subclass 4 (IgG4) (Fig