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A general weekly progression may look like: Weeks 14: introductory dose Weeks 58: first increase Weeks 912: moderate dose range Weeks 1316: continued gradual increase Weeks 1720: higher therapeutic range Week 21 onward: maintenance dose based on response Some individuals remain at moderate dose levels long-term if results are achieved without needing further increases

Optical density of bands was determined using Image J software

*%RDA - recommended daily allowance Drink 1/2 of the ampoule (12,5 ml) two times a day approx

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For example, IL-22, an effector cytokine expressed by Th17 and Th22 cells, triggers epidermal activation and hyperproliferation in psoriasis patients via STAT3 activation 13