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Despite their promise, a significant challenge in the development, formulation, and manufacturing of these therapeutics lies in the formation of complex molecular structuresranging from oligomers to aggregates and fibrils

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RC-fed Dpp4 / mice exhibited no detectable plasma DPP4 activity, an approximately 8-fold increase in plasma active GLP-1, reduced fasting glucose, improved glucose tolerance, and no difference in body weight compared with Dpp4 +/+ mice (Figure 2A and Supplemental Figure 1, A and B