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The Wells score is determined by major risk factors (recent history of surgery or bed rest, immobilization, or presence of cancer), physical exam findings (edema, engorgement, enlargement, tenderness, and superficial vein dilation in the affected limb), and history (previous DVT and absence of another likely explanation for signs and symptoms)

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It blocks NNMT , an enzyme that wastes niacin (NAM) and methyl groups, so your cells keep more NAD for mitochondrial upkeep and more SAM for healthy methylation

Epub 2002 Nov 9