Linjawi S, Bode BW, Chaykin LB et al (2017) The efficacy of IDegLira (insulin degludec/liraglutide combination) in adults with type 2 diabetes inadequately controlled with a GLP-1 receptor agonist and oral therapy: DUAL III randomized clinical trial
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Now, I dont know about you but to me that makes me think, then how can metformin have detrimental effects on exercise adaptation? I no longer worry about it
You might be an ideal candidate for an every other week dosing schedule if: You have achieved your desired weight, and you want to maintain it consistently for a long period You have well-controlled A1c and optimal blood sugar control, or your metabolic profile is within normal range for type 2 diabetes You have healthy lifestyle habits such as daily exercise, a balanced diet, an appropriate sleep schedule, and a well-established stress management routine You can closely track and monitor weight, blood sugar levels, and metabolic changes, and overcome food noise You have a strong partnership with your provider, who is easily accessible for continuous monitoring and to make necessary adjustments when needed In contrast, the following are the conditions when a biweekly schedule is not suitable for you, and you should stick to a weekly dosing schedule: You are actively losing weight and have not reached your desired weight loss goal You have uncontrolled type 2 diabetes and a higher HbA1c You experience strong hunger signals or cravings when the concentration of medication drops after 7 days You have a history of rapid weight regain in previous maintenance attempts You need a stable therapeutic dose to maintain appetite control and blood sugar levels You have a sedentary lifestyle with minimal physical activity If you fit any of these conditions, stay on weekly dosing because extending the dosing interval may increase the likelihood of returning appetite, metabolic fluctuations, and loss of progress
Serious side effects include: Thyroid cancerThe FDA has issued its most serious warning (called a Boxed Warning) that GLP-1s may be associated with a type of thyroid cancer called medullary thyroid carcinoma
Site rotation across the four abdominal quadrants, the back of the upper arm, and the outer thigh helps prevent nodules and lipohypertrophy
