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Pandemics are not only virus-driven: One of the most extensive pandemics was the Black Death from 1331 to 1353, caused by the bacterium Yersinia pestis and is estimated to have killed approximately half of Europes population 5

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BH4 is synthesized by GTP cycle hydrolase 1 (GCH1), a promising inhibitor of ferroptosis

It has been suggested that the malfunction resulting in excess protein expression may be associated with compromised synaptic function, which may result in the accumulation of scaffolding proteins such as neurofilament light chain