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May 28, 2026

The intensification of the inflammatory response is closely related to the activation of the Toll-like receptor 4 (TLR4)/Krppel-like factor 5 (KLF5)/nuclear factor-kappa B (NF-B) signaling pathway (Figure 1)

While side effects of GH administration in older adults include edema, arthralgias, and elevated blood glucose, data regarding the possible long-term effects on risk of fractures, cancer, cardiovascular disease, life expectancy, and mortality are lacking