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The most prevalent GI symptoms in the semaglutide group were: Nausea (44.2%) Diarrhea (31.5%) Vomiting (24.8%) Constipation (23.4%) Nasopharyngitis (21.5%) Dyspepsia (10.3%) Abdominal pain (10.0%) Both the semaglutide and placebo groups commonly experienced upper respiratory tract infections and headaches, indicating that these complaints were not linked to semaglutide use