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In addition, smokers were not more prone to negative treatment outcomes, although a trend was observed (adjusted odds ratio [OR] 1.24, 95% confidence interval [CI] 0.911.70), and were more likely to be lost to follow-up, but this was also not significant (adjusted hazard ratio [HR] 2.09, 95% CI 0.894.94)

Skin-related adverse events (AEs) were observed in both the SAD and MAD portions of the trial (57)

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Significant progress has been made in improving tissue healing and regeneration, but treatment options for untreated patients with chronic diabetes remain limited

Terai et al

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