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Although the concentrations are much lower than pharmacological supplement doses, dietary melatonin can be bioavailable and may contribute to circulating melatonin levels

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What I think it also might actually do, further to your points, is revitalize thinking about obesity and RA/PsA/OA and actually further research in these areas, including along the lines of what you suggest

Age Older adults tend to process drugs more slowly than younger people

Samelson-Jones BJ, Yeh SR

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