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The upregulated expression of ZIP7 facilitates the proliferation and aggression of tamoxifen-resistant MCF-7 cells by activating epithelial growth factor receptor (EGFR), insulin-like growth factor receptor 1 (IGF1R), and tyrosine kinase Src

Bhutia YD, Ganapathy V (2021) In: Feldman M, Friedman LS, Brandt LJ (eds) Sleisenger and Fordtrans gastrointestinal and liver disease, 11th ed

Glutathione is needed by the liver to filter out harmful substances and protect liver cells from damage

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Probably, the low binding affinity is an artifact of the receptor isolation, as the physiologically relevant affinity of thiamine to the receptor may require proteinprotein interaction within the native structure of the synapses