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The SURMOUNT-1 trial demonstrated 20.9% mean body weight reduction with tirzepatide 15mg weekly at 72 weeks, while preclinical 5-amino-1MQ studies showed visceral fat reduction independent of caloric restriction

Statistical analysis Statistical analyses were performed using IBM SPSS Statistics 23.0 (IBM, USA)

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Glucose-dependent insulinotropic polypeptide suppresses peripheral arterial remodeling in male mice