They discussed the difficulties they had in reaching their prespecified enrollment target
I have an old mountaineering guide that gives climbers the advice that they should take a pause every now and then during the climb so that they can smoke a cigarette as it opens up the lungs. The reality that smoking causes cancer and heart disease became only visible through careful statistical analysis

The Norwegian Health Directorate states on its website that it is considered a country with restrictive tobacco legislation[19] and it is ranked in the top five in Europe for the robustness of its tobacco control.[20] Norway was one of the first countries to ban the advertising of tobacco products[21] then, in 2004, it became only the second country, after Ireland, to bring in a national smoking ban, meaning smoking is prohibited in both workplaces and public places.[22] Norway was also the first country to ratify the Framework Convention on Tobacco Control (FCTC), which entered into force in 2005.[23] in 2023, only 7% of Norwegians aged between 16 and 74 smoked daily, meaning here are now twice as many people who use snus compared to cigarettes (16% vs 7%) This increasing stigmatisation of smoking laid the groundwork for another product to step into the place of cigarettes and Norways long cultural association with snus meant it had the potential to fill this role

As with any content element, awareness and context matter
The amount of nicotine in e-cigarettes has increased with vaping's popularity
Originally designed as a cigarette lighter, it now serves a critical role as a 12V power outlet, essential for powering devices like phone chargers, GPS units, dash cams, and portable air compressors