No clinically significant differences in the pharmacokinetics of the following drugs were observed when used concomitantly with semaglutide: lisinopril, S-warfarin, R-warfarin, metformin, digoxin, ethinyl estradiol, levonorgestrel, furosemide or rosuvastatin
Semaglutide is contraindicated for use in patients with active or a history of pancreatitis, a personal or family history of certain types of thyroid cancer, namely C cell tumors, and multiple endocrine neoplasia syndrome type 2, and hypersensitivity to the medication
But in special circumstances, including shortages, compounding pharmacies are permitted to manufacture otherwise protected drugs in order to meet demand
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Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: May cause fetal harm