Both alcohol use and alcohol related deaths increased in the US during the COVID-19 pandemic 5,6
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[1] Dose-escalation studies, such as a 12-week trial on gradual titration, revealed that beginning at lower doses (e.g., 4 mg) and slowly increasing to therapeutic levels significantly reduced the incidence of nausea, vomiting, and diarrhoea
Funding This study was funded by the High Level Chinese Medical Hospital Promotion Project (HLCMHPP2023089), the Special Programme for the Cultivation of Outstanding Young Scientific and Technological Talents (Innovation Category) under the Basic Scientific Research Fund of China Academy of Chinese Medical Sciences (ZZ13-YQ-019), and the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ-YQ2023004)
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The total weekly dose remains identical, but the peaks and troughs of drug concentration are smaller