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There are no daily peaks and troughs like with liraglutide

Furthermore, efforts directed at generating combinatorial GLP-1R agonists with one or two additional peptide agonists to achieve greater weight loss (18) in a single molecule may need to consider the effect of molecular structure on the GLP-1Rdependent uptake and activity of the hybrid agonists in the CNS

Supports hepatic detoxification and elimination of metabolites

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Bowers and colleagues demonstrated in normal men that a GH-releasing peptide given with GHRH produced GH responses substantially greater than the sum of either agent alone, and inferred from that supra-additivity that the two act through independent mechanisms

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