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Gago, B., Lundberg, J

In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation

These include: Molecular interactions between receptors Cell signalling pathways Pharmacokinetics Metabolism Human clinical trials under strict control Biomarker reactions Site-specific effects The developments in the field of peptide chemistry might lead to enhanced molecular stability, selectivity for receptors, and analytical techniques

Kalogirou MS, Patoulias D, Haidich AB, Akriviadis E, Sinakos E

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