The pivotal trials enrolled hundreds of subjects and used CT-measured visceral adipose tissue (VAT) as the primary endpoint, a harder measure than BMI or waist circumference
A 2012 study published in JAMA Internal Medicine finding that tesamorelin significantly improved executive function and verbal memory scores in adults over 60 compared to placebo over 20 weeks opened a new clinical inquiry that has not yet been fully explored in larger populations but is already informing longevity protocols in Miami and across the country
Subcutaneous injection into the abdomen for systemic effect or directly over the area you want to target for localized lipolysis
The Raun 1998 study compared ipamorelin head-to-head with GHRP-2 and GHRP-6 in rats and found that at doses producing equivalent GH release, ipamorelin caused no statistically significant increase in cortisol or prolactin, while GHRP-2 and GHRP-6 produced significant elevations of both
Glutathione helps protect cells by neutralizing free radicals and supporting detoxification, promoting healthy cell function and recovery from daily stress
Volume of Distribution (V d ) Volume of distribution ( V d ) relates amount of drug in body to plasma concentration V d = (amount of drug in the body) / (plasma drug concentration) V d is changed in disease states that decrease plasma proteins a decrease in plasma proteins decreases binding of drug to plasma proteins e.g., liver disease e.g., kidney disease V d increased in disease states that increase total body water ascites, pulmonary edema, heart failure can lower plasma concentration of water soluble drugs V d predicts drug distribution in body low V d drugs medium V d drugs high V d drugs Clearance (CL) CL = (rate of elimination of drug) / (plasma drug concentration) = V d * K e K e = elimination constant CL relates the rate of elimination to the plasma concentration Half-Life (t 1/2 ) t 1/2 = (0.7 * V d )/CL half-life is time required for amount of drug to fall to 50% of an earlier measurement during elimination or during constant infusion a drug infused at a constant rate reaches about 94% of steady state after 4 half lives for drugs eliminated by first-order kinetics, half-life is constant regardless of concentration Bioavailability (F) bioavailability is the fraction of administered dose that reaches systemic circulation bioavailability is defined as unity, or 100%, in case of IV administration bioavailability of drug administered by other routes is generally reduced by incomplete absorption, first-pass metabolism, and any distribution into other tissues that occurs before the drug enters systemic circulation e.g., orally, F = percent that is absorbed and survives first-pass metabolism in liver Calculation of bioavailabillity (F) = 100% * (AUC-oral * Dose-IV) / (AUC-IV * Dose-oral), where AUC is the area under the curve of a pharmacokinetic plasma concentration versus time plot delayed release formulations will have slower rise and lower peak compared with rapid release formulations
