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Xue Y, Zou H, Ruan Z, Chen X, Lai Y, Yao D, et al

Brain neuroimaging studies and enzymatic, transcriptomic and proteomic analyses of the autistic brain further support forms of mitochondrial dysfunction in the central nervous system (5157)

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These three tiers are generally consistent: certainty of benefit is concentrated in phenotypes related to body weight and central obesity, whereas conclusions regarding IR and reproductive outcomes are more dependent on study design and patient phenotype