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A companion 2006 study by Ionescu and Frohman found that CJC-1295 raised basal GH levels by approximately 7.5-fold and overall mean GH by 46%, while preserving the natural pulsatile pattern of GH secretion rather than abolishing it [7]

however, ligand-induced receptor downregulation markedly limits sustained efficacy

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Friedmann Angeli, J