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Notably, a propargyl group at P1 or alternatively an extended P1 side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)
[7] [8] NAD+ and NADH are continuously recycled during redox reactions, but during other metabolic activities, they are absorbed by NAD+-dependent enzymes and may subsequently become depleted over time, increasing the risk of DNA damage, age-related illnesses, and mitochondrial malfunction
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J Epithel Biol Pharmacol
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