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Once-Weekly Injection Like many GLP-1 receptor agonists, Retatrutide is administered via injection

healthcare providers licensed to prescribe Lilly medicines and is listed as a pharmacy option in all major electronic health records (EHR) systems

This showed up in trials where patients lost weight, paving the way for the development of these drugs for obesity as well

The approval positions the pill as a potential alternative to injectable GLP-1 therapies and is expected to become available in the US in early January 2026

Drugs targeting neurons alone often fail because they ignore the reciprocal signaling that glia provide

Some of these have stronger clinical support than others