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Heat-induced epitope retrieval

has acted as consultant and speaker, and received research or educational grants from Abbott, Medtronics, Novo Nordisk, Sanofi, Servier, Boehringer-Ingelheim, Eli Lilly, Johnson & Johnson, Lifescan, Roche, MSD, Novartis, Aventis, Bayer, USV, Dr

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First identified in human plasma, its concentration declines significantly with agefrom approximately 200 ng/mL in youth to 80 ng/mL by the age of 60 (Pickart and Margolina 2018)

Ethics statement The studies involving humans were approved by IEC of Institution for National Drug Clinical trials, Tangdu Hospital, Fourth Military Medical University