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The figure connects the activation of GLP-1R to downstream pathways (cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, ERK/MAPK) that regulate mitochondrial function, autophagy, proteostasis, and stress response, all of which collectively influence the hallmarks of aging to improve both cellular and systemic resilience

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Tirzepatide (dual GIP/GLP-1) orforglipron (GLP-1 only): ~5 kg gain

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And we are at a point in time, thankfully, that we have other efficacious solutions. But, she added, Sometimes just getting people actively involved in thinking about their health, even once a day [by taking a supplement], can have a big benefit